Australians Nick Kygrios and Bernard Tomic both lost overnight, as the last of the Aussie men were sent packing from the 2016 Championships.
Kyrgios faced the toughest task in the draw, coming up against world No.2 Andy Murray.
The Brit took care of the Australian in straight sets in just one hour and 43 minutes, 7-5, 6-1, 6-4.
The young Aussie admitted post-match that he needs to become mentally tougher on court.
“Just a little bit soft still. I think when things get tough, I’m just a little bit soft,” Kyrgios admitted.
Meanwhile, Bernard Tomic lost a thrilling five setter against French young gun and 32nd seed, Lucas Pouille.
Despite leading 4-2 in the fifth set, Tomic was unable to close out the match, eventually succumbing 6-4, 4-6, 3-6, 6-4, 10-8.
Murray will face Jo-Wilfred Tsonga in the quarterfinals, while Pouille will play the winner of Tomas Berdych and Jiri Vesely.